The GCLM (4G5) Monoclonal Antibody from Bioss Inc. is a Rabbit Monoclonal antibody to GCLM. This antibody recognizes Human, Mouse, and Rat antigen. The GCLM (4G5) Monoclonal Antibody has been validated for the following applications: Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunohistochemistry - fixed, and Western Blot.
Description
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms